Community-based surveillance of severe bacterial pathogens to guide prevention and control

This project involves a community-based carriage study for bacterial species that cause invasive meningococcal disease and invasive pneumococcal disease, with a focus on households in high prevalence areas. It will help to understand where transmission happens within a household and factors that might influence carriage and transmission.

 

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Principal Investigator
Xiaoyun (Una) Ren
ESR
Public Contact
Kim Thomas
teniwhacomms@otago.ac.nz
Project Timeframe/Status
-
In Process

Whakarāpopoto Rangahau Summary of Research

The project involves molecular typing and genomic sequencing of bacteria that cause meningococcal disease (IMD, Neisseria meningitidis, meningococcus) and invasive pneumococcal disease (IPD, Streptococcus pneumoniae, pneumococcus) to identify transmission events and get a better understanding of the diversity of circulating meningococci and pneumococci.

Expected outcomes of the study are:

  • understanding carriage burden in different populations in Aotearoa New Zealand
  • identifying factors and behaviours that may influence carriage rate and transmission
  • a better understanding of the diversity of circulating meningococcus and pneumococcus in Aotearoa New Zealand.

Te Hiranga a Rangahau Research Impact

Better understanding of carriage will lead to more evidence-based health policy, immunisation policy and vaccine procurement decision making. 

The relationship between high carriage and disease development is not clear. It is likely dependent on the strain of pathogen being carried. A carriage survey where Māori and Pacific participants are equally represented or enriched, will clarify relationships between carriage and disease in Aotearoa New Zealand.
 
The study will also identify specific risk factors and devise possible mitigation strategies to reduce transmission. 

Sharing the results with the community could push IMD and IPD awareness to the forefront and create opportunities to increase immunisations. Understanding housing conditions or household behaviour that lessens or exasperates transmission could inform housing standards and contribute to the design of mitigation tools.

An important long-term impact of this project is the relationship formed with local Māori and Pacific communities. The goal is to empower communities, build local capability and capacity, increase public health surveillance knowledge, create a trusting approach that allows proactivity and engagement with these services to improve the health and well-being of whānau. Information could also be used at a national level to inform vaccine funding as well as identifying appropriate vaccinations and populations for inclusion in the national immunisation programme.

Te Niwha

Kairangahau Research Personnel

Xiaoyun (Una) Ren
ESR
Leader

Prof Philip Hill
University of Otago
Leader

Emma Best
University of Auckland
Key Researcher

Tia Haira
ESR
Key Researcher

Sarah Jefferies
ESR
Key Researcher

 

Amanda Kvalsvig
University of Otago
Key Researcher

Sue McAllister
University of Otago
Key Researcher

Conor Watene O'Sullivan
The Moko Foundation
Key Researcher: Kaupapa Māori expertise, Northland Community enagement, tamariki health

Gerard Sonder
Pacific Perspectives Ltd / University of Amsterdam
Key Researcher: epidmiological expertise, Pacific community expertise, well advise on study design, data interpretation and community engagement

LOCATIONS

Auckland, Northland

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