Examining the potential of PI3K inhibitors as flavivirus antivirals for diseases such as Zika and Dengue Fever

Masters Scholarship
MEGHNA PATEL

Meghna headshot v2
Principal Investigator
Meghna Patel
University of Auckland
Public Contact
Kim Thomas
teniwhacomms@otago.ac.nz
Project Timeframe/Status
-
In Process

Whakarāpopoto Rangahau Summary of Research

Global warming is driving the spread of mosquito-borne viral infections such as dengue and Zika (both known as flaviviruses) beyond the tropics to have a much larger habitat around the world. There have been larger outbreaks of dengue, in areas such as Northern Europe, that have not previously been warm enough to support the virus-carrying mosquito’s lifecycle.

The predicted temperatures in Northern parts of Aotearoa New Zealand are edging closer to those that will support the overwintering of the Aedes species of mosquitoes, allowing dengue and Zika transmission here, as has been seen in neighbouring Pacific nations. There are currently no approved antiviral treatments for either Zika or dengue, and no vaccines for Zika, while the two approved dengue vaccines are largely inaccessible.

To ensure that Aotearoa New Zealand is prepared to meet this new health threat head on, safe and effective antivirals to combat these viruses are urgently required.

Te Hiranga a Rangahau Research Impact

This project aims to address the lack of specific treatments for dengue and Zika infection, which both carry a significant risk for illness, and in severe cases, death. This research is significant for Aotearoa New Zealand as we are already feeling the devastating impacts of global warming. As our temperatures increase further, it will be warm enough to support the full lifecycle of Aedes mosquitoes, which would allow transmission of several disease-causing viruses including dengue, Zika, chikungunya and yellow fever in Aotearoa, putting our health at risk.

Te Niwha

Kairangahau Research Personnel

Dr Natalie Netzler
University of Auckland
Primary Supervisor

Prof Peter Shepherd
University of Auckland
Supervisor