Genomics-informed detection, surveillance and capacity building to prepare Aotearoa for the existential threat of highly pathogenic avian influenza virus

Collecting environmental samples such as bird faeces will help understand how and where avian influenza and other potentially devastating viruses could impact Aotearoa New Zealand as the highly infectious H5N1 spreads globally.

birds flying v2
Principal Investigator
Prof Jemma Geoghegan, Dr David Winter
University of Otago & the Institute for Environmental Science & Research (ESR)
Public Contact
Kim Thomas
teniwhacomms@otago.ac.nz
Project Timeframe/Status
-
In Process

Whakarāpopoto Rangahau Summary of Research

Wild aquatic birds carry a panoply of viruses and act as major vectors of virus distribution at a global scale. Although central to biosecurity, the role that such birds play in the transmission of viruses in Aotearoa, and how this may impact human and animal health in the near future, is unclear. These viruses often jump to new hosts and cause disease. 

For example, wild aquatic birds such as waterfowl serve as natural reservoirs for influenza A virus, a strain of which is currently killing millions of birds with multiple spillovers to non-avian hosts, including humans. Yet we know little about where, when and how such viruses will emerge here, their reservoir hosts, nor how to prevent them.

This lack of knowledge, combined with very limited surveillance and resources, leaves Aotearoa entirely unprepared for the introduction of highly pathogenic avian influenza virus and its inevitable impacts on wildlife, agriculture and potentially human health.

Using an innovative combination of genomics technologies such as metagenomics, molecular epidemiology and environmental DNA (eDNA), we will determine the transmission networks and evolution of avian influenza strains already present in Aotearoa, demonstrate the use of large-scale environmental sampling for disease surveillance, and quantify the disease risk of such viruses to public health. 

Kairangahau Research Personnel

Prof Jemma Geoghegan
University of Otago
Leader

David Winter
ESR
Leader

Dr Allison Miller
University of Otago
Postdoctoral Fellow

Lia Heremia
University of Otago
Honours Student

Stephanie Waller
University of Otago
Postdoctoral Fellow

Vinko Besic
ESR
Collaborator

Dr Eddy Dowle
Plant and Food Research
Collaborator

Marie Moinet
University of Otago
Advisor

Harry Taylor
Ministry for Primary Industries
Advisor

Mike Bunce
Department of Conservation
Advisor

Neil Gemmell
University of Otago
Advisor

Kate McInnes
Department of Conservation
Advisor

Richard Webby
St Jude Children's Research Hospital
Advisor

Michelle Wille
University of Melbourne
Advisor

Vijaykrishna Dhanasekaran
Hong Kong University
Advisor

Eddie Holmes
University of Sydney
Advisor

Matauranga Publication

Avian influenza virus surveillance across New Zealand and its subantarctic islands detects H1N9 in migratory shorebirds, but not 2.3.4.4b HPAI H5N1

Stephanie J Waller, Janelle R Wierenga, Lia Heremia, Jessica A Darnley, Isa de Vries, Jeremy Dubrulle, Zoe Robinson, Allison Miller, Chris N Niebuhr, David Melville, Rob Schuckard, Phil F Battley, Michelle Wille, Rosalind Cole, Kate McInnes, David Winter, Jemma L Geoghegan