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Understanding the Ubiquitination and Characterisation of Atypical Kinase RIOK3

PhD Scholarship
JACQUELINE ORMSBY

Jacqueline Ormsby v2
Principal Investigator
Jacqueline Ormsby
University of Canterbury
Public Contact
Kim Thomas
teniwhacomms@otago.ac.nz
Project Timeframe/Status
-
In Process

Whakarāpopoto Rangahau Summary of Research

Rift Valley Fever Virus (RVFV) poses a serious global health risk, causing severe illness in both animals and humans. In livestock, it leads to nearly 100% abortion rates, and in humans, it may increase the risk of miscarriage. A key protein called RIOK3 plays an important role in the immune response to RVFV, but its exact function is still not well understood. This research aims to study RIOK3 in detail to uncover its role in fighting the virus.

The main objectives of the research are:

  1. To determine the structure of RIOK3.
  2. To identify where RIOK3 binds to a protein called ubiquitin and measure how strongly it binds.
  3. To understand how RIOK3 and ubiquitin together affect the immune response to RVFV.
  4. To identify other molecules that interact with RIOK3 in different signalling pathways.
  5. To explore potential drugs that could block RIOK3’s interaction with ubiquitin.

To achieve these goals, RIOK3 will first be produced using insect cells and then purified through advanced techniques. The purified protein will be used to study its structure and its interaction with ubiquitin. Mouse models will help reveal how RIOK3’s role in the immune response against RVFV. Finally, potential drugs that could influence these interactions will be investigated.

Te Hiranga a Rangahau Research Impact

This project aims to strengthen New Zealand's research capabilities in responding to significant infectious disease threats, particularly Rift Valley Fever Virus (RVFV). By addressing this threat, the research contributes to building robust frameworks for tackling infectious diseases. Furthermore, the project promotes capacity building by actively involving local researchers and students, fostering skills and expertise in the field. It also connects with the broader research community to share knowledge and best practices.

If successful, this research will enhance our understanding of the immune response and how the body reacts to viral infections. It seeks to translate this fundamental knowledge of RIOK3 into practical applications for antiviral therapies, potentially leading to new strategies for combating viral diseases. The findings from this research will be disseminated through various channels, including peer-reviewed publications, conference presentations, and community hui, ensuring that the insights gained reach both the scientific community and the public. By engaging with diverse audiences, the project aims to raise awareness and inform strategies for managing infectious diseases effectively.

Te Niwha

Kairangahau Research Personnel

Prof Renwick Dobson
University of Canterbury
Primary Supervisor

Prof David Komander
Walter and Eliza Hall Institute of Medical Research
Supervisor